https://www.aceprehealth.com/blogmasonry daily 0.75 2026-03-19 https://www.aceprehealth.com/blogmasonry/k5l4mkknrnbbbgcdtbzc6l7wy3z9hb monthly 0.5 2026-03-10 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1773172027274-V6MH4JFIBGT409B1LO6R/Gemini_Generated_Image_6lgm616lgm616lgm.png 文章数据库 - 吸烟使大脑萎缩 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.aceprehealth.com/blogmasonry/6339dy392xfed3wtd6s2hmz2mlsbfy monthly 0.5 2026-03-10 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1773171543842-9KL7XF3AT9LM9JBUCW26/ChatGPT+Image+Mar+10%2C+2026%2C+03_38_14+PM.png 文章数据库 - 漂亮蘑菇 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.aceprehealth.com/blogmasonry/pegsmeekklc2he36a88t4szkfwbttl monthly 0.5 2026-03-10 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1773170396411-0G4RFVPRIV9CV6JVMW3L/ChatGPT+Image+Mar+10%2C+2026%2C+03_19_36+PM.png 文章数据库 - 植化素膳食补充剂 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.aceprehealth.com/blogmasonry/xfnjarxe8jcmcenr546k4mz55sr82y monthly 0.5 2026-03-10 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1773170118588-3B94V9SC90XJNHZMR64A/ChatGPT+Image+Mar+10%2C+2026%2C+03_14_48+PM.png 文章数据库 - 为什么要吃五颜六色的蔬果？ - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.aceprehealth.com/blogmasonry/xmnkg5zz83zbfpa25wmh8jn2d235fy monthly 0.5 2026-03-10 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1773169507110-QDDO7E6TE13BVG9SMP9Q/unnamed.jpg 文章数据库 - 高血压，炎症，与痴呆症 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.aceprehealth.com/blogmasonry/jeprb9366pdh364g2xhd7t9r9zbh6h monthly 0.5 2026-03-10 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1773163229442-O8U3WCVDAFV1E52FQ7P3/Gemini_Generated_Image_ukpf5jukpf5jukpf.png 文章数据库 - 长寿的基辛格 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.aceprehealth.com/blogmasonry/snz9kc4p7cw6fkgme2j3ele7xl7mwb monthly 0.5 2026-03-10 https://www.aceprehealth.com/blogmasonry/nd6eh1uo80toi4gjt566b6pv9ghz1d monthly 0.5 2026-03-10 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1773162239472-K0XJXO0018TATLJ16HTX/c5464842-6de5-49e6-94da-ca3296865112.png 文章数据库 - 肠道菌群如何影响大脑功能 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.aceprehealth.com/blogmasonry/hcd8pgsjyzfn4kd9mlmw5xyh3y4734 monthly 0.5 2026-03-10 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1773161421987-M5ZOU9KJHE04AZ6QF4WE/Gemini_Generated_Image_u2p828u2p828u2p8.png 文章数据库 - 肠道菌群 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.aceprehealth.com/blogmasonry/8rk2apm7ljbe5kpzwektkn44y4cgm2 monthly 0.5 2026-03-10 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1773160957684-78YYXBZFXV5RV94J8LYN/Gemini_Generated_Image_lnaxlelnaxlelnax.png 文章数据库 - 心情与风景 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.aceprehealth.com/blogmasonry/zbfwe2hl5ffs4wgb75rjgldd4pzsg5 monthly 0.5 2026-03-10 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1773160572556-13QVLQUB6FYHYM2ZC14E/Gemini_Generated_Image_ml7o8sml7o8sml7o.png 文章数据库 - 脱发 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.aceprehealth.com/blogmasonry/rakssgbtl2mm96emdt9ytajjxhnamc monthly 0.5 2026-03-10 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1773156947021-QCU5J7MH7DAVP5PNW5F9/Gemini_Generated_Image_olcenjolcenjolce.png 文章数据库 - 胃镜，有趣的麻醉医生，胃息肉 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.aceprehealth.com/blogmasonry/hpvhpv monthly 0.5 2026-03-10 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1773155767418-0AIWUCE1MS54BXK9Q689/Gemini_Generated_Image_stf16estf16estf1.png 文章数据库 - 关于HPV和HPV疫苗的几个问题 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.aceprehealth.com/blogmasonry/728a2dnx2dm9m28jfz5hraeambpddx monthly 0.5 2026-03-10 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1773154443366-AHFEHFBTB56IA4KBPO5I/Gemini_Generated_Image_n6czmkn6czmkn6cz.png 文章数据库 - 感恩与身心健康 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.aceprehealth.com/blogmasonry/ymrylxgtdkrdrzerhraakt288c6nar monthly 0.5 2026-03-10 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1773152979914-QLGGMG2X6BZOJ2GC0E35/Gemini_Generated_Image_71kg8971kg8971kg.png 文章数据库 - 生活方式、表观遗传与衰老 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.aceprehealth.com/blogmasonry/k52m8rxfdsa5akf3nhy78kfcjmd8ts monthly 0.5 2026-03-10 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1773152549990-JO3N3F251AVB6NSFUI85/Gemini_Generated_Image_p04rudp04rudp04r.png 文章数据库 - 生活方式、表观遗传和癌症风险 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.aceprehealth.com/blogmasonry/hyzc69km9k9edhs8dyr8gbmexg68t8 monthly 0.5 2026-03-10 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1773151759292-LD7SXYZ6Z98G2TT4IT6Z/Gemini_Generated_Image_yjwpehyjwpehyjwp.png 文章数据库 - 什么是表观遗传学？ - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.aceprehealth.com/blogmasonry/ry3kkk4rtpzytjrcmw4a49txm7z7y4 monthly 0.5 2026-03-10 https://www.aceprehealth.com/blogmasonry/7yb8l67kgf6ye985pzntzr5kzm7zxs monthly 0.5 2026-03-10 https://www.aceprehealth.com/blogmasonry/s9zsrwcerc9c9dgbs73wz56lrt9tlg monthly 0.5 2026-03-10 https://www.aceprehealth.com/blogmasonry/4tbvqvilr50fiqjl410ejnsp384744 monthly 0.5 2026-03-10 https://www.aceprehealth.com/blogmasonry/j59p66ezjye4k4rpy438zdry6pbd47 monthly 0.5 2026-03-10 https://www.aceprehealth.com/blogmasonry/3bszazsetgf3yl76c6rfh886jphyce monthly 0.5 2026-03-10 https://www.aceprehealth.com/blogmasonry/r37kaztw7yzj4t886gs3bt95lsw9dr monthly 0.5 2026-03-10 https://www.aceprehealth.com/blogmasonry/d75zdfjcfnwp9m9rd5ckdmx7bs4sy4 monthly 0.5 2026-03-10 https://www.aceprehealth.com/blogmasonry/nbsp monthly 0.5 2026-03-09 https://www.aceprehealth.com/blogmasonry/79t5wsy5gkwz9eahjmkff8hk3fgbhd monthly 0.5 2026-03-09 https://www.aceprehealth.com/blogmasonry/7emsg3dcxt58dr4s9sasap8y9cxpf2 monthly 0.5 2026-03-09 https://www.aceprehealth.com/blogmasonry/fse2gzn8449c2yzjlpgry9s54bp7tb-m89b4-4nagp-9xehw-c3zbx-ec352-p74sp-6ywd5-jdthb-wscs8-5xl8j-b39e2-ddngh-dzmzd-y49xz-wdnxz monthly 0.5 2026-03-02 https://www.aceprehealth.com/blogmasonry/fse2gzn8449c2yzjlpgry9s54bp7tb-m89b4-4nagp-9xehw-c3zbx-ec352-p74sp-6ywd5-jdthb-wscs8-5xl8j-b39e2-ddngh-dzmzd-y49xz monthly 0.5 2026-03-02 https://www.aceprehealth.com/blogmasonry/fse2gzn8449c2yzjlpgry9s54bp7tb-m89b4-4nagp-9xehw-c3zbx-ec352-p74sp-6ywd5-jdthb-wscs8-5xl8j-b39e2-ddngh-dzmzd monthly 0.5 2026-03-02 https://www.aceprehealth.com/blogmasonry/fse2gzn8449c2yzjlpgry9s54bp7tb-m89b4-4nagp-9xehw-c3zbx-ec352-p74sp-6ywd5-jdthb-wscs8-5xl8j-b39e2-ddngh monthly 0.5 2026-03-02 https://www.aceprehealth.com/blogmasonry/fse2gzn8449c2yzjlpgry9s54bp7tb-m89b4-4nagp-9xehw-c3zbx-ec352-p74sp-6ywd5-jdthb-wscs8-5xl8j-b39e2 monthly 0.5 2026-03-02 https://www.aceprehealth.com/blogmasonry/fse2gzn8449c2yzjlpgry9s54bp7tb-m89b4-4nagp-9xehw-c3zbx-ec352-p74sp-6ywd5-jdthb-wscs8-5xl8j monthly 0.5 2026-03-02 https://www.aceprehealth.com/blogmasonry/fse2gzn8449c2yzjlpgry9s54bp7tb-m89b4-4nagp-9xehw-c3zbx-ec352-p74sp-6ywd5-jdthb-wscs8 monthly 0.5 2026-03-02 https://www.aceprehealth.com/blogmasonry/fse2gzn8449c2yzjlpgry9s54bp7tb-m89b4-4nagp-9xehw-c3zbx-ec352-p74sp-6ywd5-jdthb monthly 0.5 2026-03-02 https://www.aceprehealth.com/blogmasonry/fse2gzn8449c2yzjlpgry9s54bp7tb-m89b4-4nagp-9xehw-c3zbx-ec352-p74sp-6ywd5 monthly 0.5 2026-03-02 https://www.aceprehealth.com/blogmasonry/fse2gzn8449c2yzjlpgry9s54bp7tb-m89b4-4nagp-9xehw-c3zbx-ec352-p74sp monthly 0.5 2026-03-02 https://www.aceprehealth.com/blogmasonry/fse2gzn8449c2yzjlpgry9s54bp7tb-m89b4-4nagp-9xehw-c3zbx-ec352 monthly 0.5 2026-03-02 https://www.aceprehealth.com/blogmasonry/fse2gzn8449c2yzjlpgry9s54bp7tb-m89b4-4nagp-9xehw-c3zbx monthly 0.5 2026-03-02 https://www.aceprehealth.com/blogmasonry/fse2gzn8449c2yzjlpgry9s54bp7tb-m89b4-4nagp-9xehw monthly 0.5 2026-03-02 https://www.aceprehealth.com/blogmasonry/fse2gzn8449c2yzjlpgry9s54bp7tb-m89b4-4nagp monthly 0.5 2026-03-02 https://www.aceprehealth.com/blogmasonry/fse2gzn8449c2yzjlpgry9s54bp7tb-m89b4 monthly 0.5 2026-03-02 https://www.aceprehealth.com/blogmasonry/fse2gzn8449c2yzjlpgry9s54bp7tb monthly 0.5 2026-03-19 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1772419025991-GN5231ULZ96BQJZTIL5P/Gemini_Generated_Image_epc0amepc0amepc0.png 文章数据库 - 新概念：健康光谱 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.aceprehealth.com/blogmasonry/category/%E5%85%AC%E5%85%B1%E5%8D%AB%E7%94%9F%E4%B8%8E%E8%80%81%E9%BE%84%E5%8C%96 monthly 0.5 https://www.aceprehealth.com/blogmasonry/category/%E5%8C%BB%E5%AD%A6%E4%BA%BA%E6%96%87%E4%B8%8E%E5%8E%86%E5%8F%B2%E5%93%B2%E6%80%9D monthly 0.5 https://www.aceprehealth.com/blogmasonry/category/%E8%90%A5%E5%85%BB%E4%B8%8E%E7%94%9F%E6%B4%BB%E6%96%B9%E5%BC%8F monthly 0.5 https://www.aceprehealth.com/blogmasonry/category/%E8%84%91%E5%81%A5%E5%BA%B7%E4%B8%8E%E6%85%A2%E7%97%85 monthly 0.5 https://www.aceprehealth.com/en/current-projects daily 0.75 2024-09-16 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/f48d95d5-2320-44b2-b3ec-5983e8a628c3/Emodin-CAVD-R41.png Projects - Develop natural compound emodin as a novel therapy for calcific aortic valve disease (R41HL172481) Calcific aortic valve disease (CAVD) is a common progressive heart disease. It ranges from aortic valve sclerosis to aortic valve stenosis, characterized by aortic valve calcification with impaired leaflet function. CAVD affects 25% of the population over 65 years of age and about 50% of those over 85 years old. Currently, the standard-of-care treatment of CAVD is surgical valve replacement. There are no drugs approved by the FDA for CAVD treatment. Aberrant transforming growth factor β (TGFβ) signaling plays a key role in the pathogenesis of CAVD. We developed in vitro cell culture and in vivo mouse models that display aberrant TGFβ signaling and can be used for the development of drugs for CAVD prevention and treatment. Using these models, we found that natural compound emodin could block the progression of valve interstitial cells calcification in vitro and attenuate aortic valve calcification in mice. In this STTR Phase 1 project, we will test a hypothesis that emodin may block the development and progression of CAVD and even lead to a reversal of CAVD by tempering the aberrant TGFβ signaling. These studies will enable us to collect data towards filing an investigational new drug (IND) application to FDA. https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/266117de-18dd-4f4c-a80e-9a61e3ffd610/NAC-AD-R41.png Projects - Develop a novel strategy to deliver N-acetylcysteine for AD treatment (NIH R41AG087769) After decades of intensive research and drug development efforts, there are still no cures or substantially effective treatments for Alzheimer’s disease (AD). Studies of AD have been mainly focused on Aβ plaques and tau protein-formed neurofibrillary tangles in the brain. However, in recent years, it is increasingly clear that the development of AD is the collective consequence of the toxicities induced by Aβ plaques, tau protein-formed neurofibrillary tangles, and malfunctions of microglia. Nacetylcysteine (NAC) is a derivative of amino acid cysteine; it has been studied for its potential effects on AD, largely due to its antioxidant and anti-inflammatory activities, particularly its beneficial effects on microglia. However, NAC cannot penetrate the BBB and reach the brain sufficiently. To realize NAC’s potential as an AD treatment, we developed a brain targeted NAC delivery system (TN-NAC). Our preliminary data demonstrate that TN-NAC can effectively cross the BBB, quench the elevated ROS, attenuate the activation of microglia, reduce Aβ burden, and eliminate senescent cells in the brain in an AD mouse model, and improve the performance of the animals in behavior tests. Based on these exciting data, in this Phase I STTR study, we will test the feasibility to develop TN-NAC as a therapy for AD. https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/8276e719-1b6f-4bdf-8b7e-b75e15ca9dcc/R41AI174362.png Projects - Targeting macrophage maladaptation for bacterial sepsis treatment (NIH R41AI174362) Bacterial sepsis is a severe and potentially life-threatening condition that occurs when the body's response to bacteria damages its own tissues and organs. It can lead to shock, multiple organ failure, and death. It is increasingly clear that sepsis is a bi-phasic process comprised of 1) an early high-energy demanding hyperinflammation state that can cause inflammatory shock and 2) a low-energy supply immunosuppression state that promotes immunometabolic paralysis while countering oxidative damage. These two phases are seamlessly connected or even concurrent. This makes sepsis treatment extremely difficult, and many therapies, such as anti-inflammatory corticosteroids, often worsen the outcome. We are developing a promising new treatment for bacterial sepsis; it is a small-molecule synthetic compound called JX06. JX06 works by blocking a protein called pyruvate dehydrogenase kinase 1 (PDHK1). PDHK1 is involved in macrophage glucose metabolism and inflammation; blocking it can help to reduce inflammation and prevent cell death. In this STTR project funded by the National Institute of Allergy and Infectious Diseases (NIAID), we propose 1) to determine the toxicity of JX06 in cultured primary mouse and human cells in vitro and mice in vivo, and to study its pharmacokinetics in mice; and 2) to establish the effectiveness of JX06 in various mouse strains using the mouse cecal ligation and puncture (CLP) sepsis model. https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/5eaf281b-d6c7-45eb-aa4b-87b3699c6a0f/UT1AA030690.png Projects - Developing natural compound emodin as a therapy for alcoholic cardiomyopathy (NIH UT1AA030690) Alcohol abuse is a widespread problem that harms many organs in the body, including the heart. A condition called alcoholic cardiomyopathy (ACM) can develop following long-time alcohol use, leading to heart failure. ACM is characterized by the weakening of the heart muscle and the enlargement of the heart chambers. Currently, there are no approved treatments for ACM. Scientists at AcePre are developing the natural compound emodin as a potential preventive and therapeutic agent for ACM. Emodin has various beneficial effects, including reducing inflammation and preventing fibrosis (excessive tissue scarring). We have found that emodin can inhibit the transforming growth factor beta (TGFβ) signaling pathway, which is involved in the development of cardiac fibrosis. We have also observed that emodin protects heart cells from alcohol-induced damage and reduces fibrosis in mouse models. With the support of a STTR grant from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), we are performing further studies to investigate the safety and effectiveness of emodin in mouse, rat and pig models of ACM. https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/5db7404f-a694-46f7-bee9-40686ced82e9/R41AG081124.png Projects - The development of a multifunctional nanoenzyme for AD treatment (NIH R41AG081124) Alzheimer's disease (AD) is a progressive neurodegenerative disease and is the most common cause of dementia, which is a general term for memory loss and cognitive decline. It is named after Dr. Alois Alzheimer, who first described the disease in 1906. The disease is characterized by the formation of amyloid plaques (abnormal clumps of a protein called β-amyloid) and neurofibrillary tangles (aggregates of the tau protein) in the brain, along with a loss of connections between neurons. The cause of AD is largely unknown, and inflammation and oxidative stress in the brain are believed to contribute to the pathogenesis. Currently there is no cure for this disease. Existing medicines including the most used drug Aricept and the recently approved drug Leqembi can only slightly slow down the progression of the disease. More effective drugs are urgently needed. Our scientists at AcePre are developing a new AD treatment. We propose to deliver an anti-inflammatory and antioxidative agent cerium oxide using a novel type of nanoparticles with brain targeting property, called T-CeNP. We expect that T-CeNP can effectively get into the brain and exert its strong anti-inflammatory and antioxidative activities in the brain, thereby reducing β-amyloid deposition and tau protein aggregation. In this small business grant funded by the National Institute of Aging (NIA), we will test the safety and efficacy of T-CeNP using mouse models of AD. https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1626890009581-9NLDJ9JS8F2H640X5J74/IMG_9D53ED2EE0F0-1.jpeg Projects - Using Novel Natural Compound Sparstolonin B to Treat Bacterial Sepsis (NIH R41AI157378) Sepsis results from an infection of microorganisms, with bacteria being the most common culprit. Pathogen-associated molecular patterns (PAMPs) such as lipopolysacchardies (LPS) activate innate immune cells and tissue resident cells. Some of these activated immune cells, such as macrophages, engulf and kill the invading microbes. While these activated macrophages can do good things such as kill microbes and limit infection, they can also cause a very strong inflammatory response by secreting excessive amounts of cytokines and oxidative molecules, which can lead to tissue damage. These damaged tissues release endogenous damage-associated molecular patterns (DAMPs), which act on toll-like receptors (TLRs) to further escalate the inflammatory cascade on immune cells and tissue resident cells. This leads to multi-organ injury and eventually death. The quick evolution and complexity of the pathology of bacteria sepsis makes it extremely difficult to treat. We have isolated a new compound named Sparstolonin B (SsnB) and characterized it as a TLR2/4 antagonist, effectively inhibiting inflammatory responses. On the basis of these achievements, our long-term goal is to develop SsnB as a novel therapy for bacterial sepsis. https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1626894946401-H6QFZJ1BOHTTVF2W3IQP/IMG_D72C52AAB50A-1.jpeg Projects - A Novel Polymer-metal Nanocomplex for Ovarian Cancer Treatment (R41CA254500) Ovarian cancer is the leading cause of death from gynecologic malignancy. Most women are diagnosed with metastatic ovarian cancer, and the 5-year survival rate for this late stage disease is less than 28%. The mainstay of treatment for ovarian cancer entails debulking cytoreductive surgery in combination with adjuvant chemotherapies. Unfortunately, severe side effects of these chemotherapies compromise the quality of life and result in poor patient compliance, and the relapse rate is high due to intrinsic and acquired therapy resistance. Therefore, there is a pressing need for the development of new safe and effective treatment strategies. Our group has developed a novel pH and redox potential dual responsive polymer, poly[(2-(pyridin- 2-yldisulfanyl)-co-[poly(ethylene glycol)]] (PDA-PEG), which can be degraded intracellularly. If used as a drug carrier, this polymer system significantly improves the cancer cell killing effect and potentially reduces the off-target toxicity of the carried chemotherapeutic drugs. More excitingly, follow-up studies revealed that the combination of PDA-PEG and copper ions, termed polymer-metal nanocomplex (PMC), without being loaded with any chemotherapeutic drugs, could effectively kill a large variety of cancer cells, including drug-resistant ovarian cancer cells. Importantly, the PMC showed excellent cancer cell-selective killing. Based on these technology advancements and exciting in vitro and in vivo results, our goal is to eventually develop the PDA-PEG/Cu PMC into a novel safe and effective therapy for ovarian cancer and possible other malignant tumors. https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1626880880276-6FCFY8CXOB1ET7QKJ72Y/IMG_7406B0A2F7F6-1.jpeg Projects - Development of Dietary Quercetin to Treat Muscle Wasting Disorders (NIH R43AT011171) Cachexia is the unintentional loss of body weight resulting in reduced physical function, a decreased tolerance for treatment, and increased mortality rates. It is commonly seen in chronic diseases and associated treatments. Cachexia has been reported following chemotherapy treatment. Furthermore, the loss of lean muscle mass associated with cachexia impairs chemotherapy treatment tolerance. Currently, there are no approved therapies for cachexia. Quercetin, a natural polyphenol that is found in various fruits and vegetables, has been recognized for its anti-inflammatory properties and its ability to increase mitochondrial biogenesis. We have reported that quercetin can reduce cancer-induced cachexia, reduce the physical fatigue associated with chemotherapy, increase physical performance by increasing mitochondrial biogenesis, and reduce inflammation in a number of disease models. Our long-term goal is to have quercetin established alongside chemotherapy regimes in order to reduce the side effects of chemotherapy, thereby improving the efficacy of the treatment and patients’ quality of life. https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1626805391656-Z887EC1RDYF969DXILE5/IMG_0034.jpg Projects - Emodin as a Complementary Dietary Therapy to Reduce Toxicity of 5 Fluorouracil (NIH R41AT009964) 5 fluorouracil (5FU) has been the first-choice chemotherapy drug for colorectal cancer (CRC) for many years. However, its clinical utility remains hindered by hematopoietic and gastrointestinal toxicities resulting from its non-selectivity, resulting in side effects such as fatigue, loss of appetite, and diarrhea. Given that inflammation has been linked to 5FU-associated toxicities, targeting inflammation may minimize anticancer agent-associated toxicity, optimize cancer treatment dosing, and improve clinical outcomes. Therefore, identifying strategies to reduce the toxicity of 5FU is critical to prevent discontinued or deescalated treatment. Emodin, a natural anthraquinone derivative found in various Chinese medicinal herbs, has been recognized for its ability to target NF-κB and subsequently reduce inflammation. We have found that emodin is an effective anti-inflammatory agent that acts directly on NF-κB, is effective at reducing tumorigenesis, can abolish 5FU chemotherapy-induced intestinal inflammation and mucositis, and is indicated to be able to offset other side effects associated with 5FU chemotherapy. We have also shown that the dose of emodin that promotes these benefits does not exhibit side effects. The long-term goal for this project is to have this complementary dietary compound utilized as an innovative agent with chemotherapy. https://www.aceprehealth.com/cn/home daily 0.75 2023-10-24 https://www.aceprehealth.com/cn/projects daily 0.75 2025-02-18 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/f48d95d5-2320-44b2-b3ec-5983e8a628c3/Emodin-CAVD-R41.png 项目介绍 - 开发天然化合物大黄素作为钙化性主动脉瓣疾病的新型疗法(NIH R41HL172481) 钙化性主动脉瓣病 （CAVD） 是一种常见的进行性心脏病，可表现为从主动脉瓣硬化到主动脉瓣狭窄等不同程度的病变，其特征是主动脉瓣钙化伴瓣叶功能受损。CAVD 影响了 25% 的 65 岁以上人口和约 50% 的 85 岁以上人口。目前，CAVD 的标准治疗是手术瓣膜置换术。目前尚没有经FDA 批准的用于治疗 CAVD 的药物。 异常的转化生长因子 β （TGFβ） 信号在 CAVD 的发病机制中起关键作用。 我们开发了显示异常 TGFβ 信号传导的细胞培养模型和小鼠模型，可用于开发预防和治疗 CAVD 的药物。使用这些模型，我们发现天然化合物大黄素可以在体外阻断瓣膜间质细胞钙化的进展，并减轻小鼠主动脉瓣钙化。在这个 STTR 1 期项目中，我们将检验大黄素能否通过抑制异常的 TGFβ 信号传导而阻断甚至逆转CAVD 的进展。这些研究将使我们能够收集数据，以便向 FDA 提交研究性新药 （IND） 申请。 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/266117de-18dd-4f4c-a80e-9a61e3ffd610/NAC-AD-R41.png 项目介绍 - 开发一种新方法来递送 N-乙酰半胱氨酸用于治疗 阿尔茨海默病(NIH R41AG087769) 经过数十年的深入研究和药物开发努力，阿尔茨海默病 （AD） 仍然没有治愈方法或非常有效的治疗方法。AD的研究主要集中在大脑中的 Aβ 斑块和 tau 蛋白形成的神经原纤维缠结上。然而，近年来，越来越明显的是 AD的发展是 Aβ 斑块、tau 蛋白形成的神经原纤维缠结和小胶质细胞功能障碍诱导的毒性的共同结果。 Nacetylcysteine （NAC） 是氨基酸半胱氨酸的衍生物; 它对 AD 的潜在治疗作用已被研究，主要是由于其抗氧化和抗炎活性，特别是它对小胶质细胞的有益作用。然而，NAC 无法穿透 血脑屏障（BBB） 而充分到达大脑。为了发掘 NAC 作为 AD 治疗的潜力，我们开发了一种特异性地导向大脑的 NAC 递送系统 （TN-NAC）。我们的初步数据表明，在 一种AD小鼠模型中，TN-NAC 可以有效穿过 BBB，淬灭升高的 ROS，减弱小胶质细胞的激活，减少 Aβ 负荷，消除大脑中的衰老细胞，提高动物在行为测试中的表现。基于这些令人兴奋的数据，在这项 I 期 STTR 研究中，我们将测试开发 TN-NAC 作为 AD 疗法的可行性。 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/8276e719-1b6f-4bdf-8b7e-b75e15ca9dcc/R41AI174362.png 项目介绍 - 逆转巨噬细胞适应不良以治疗细菌性败血症 (NIH R41AI174362) 细菌性败血症是一种可能危及生命的严重疾病，在当人体对细菌的反应损害自身组织和器官时发生。 它可能导致休克、多器官衰竭和死亡。 越来越多的证据显示，脓毒症是一个双相过程，包括：1）早期高能量需求的过度炎症状态，可导致炎症休克；2）对抗氧化损伤时造成的低能量供应的免疫抑制状态，促进免疫代谢麻痹。 这两个阶段是无缝连接的，甚至同时发生。 这使得脓毒症的治疗变得极其困难。许多疗法，例如皮质类固醇抗炎剂，往往会使病情更恶化。 我们正在开发一种细菌性败血症新疗法； 它是一种小分子合成化合物，称为JX06。 JX06 通过阻断一种名为丙酮酸脱氢酶激酶 1 (PDHK1) 的蛋白质发挥作用。 PDHK1参与巨噬细胞葡萄糖代谢和炎症； 阻断它可以帮助减少炎症并防止细胞死亡。 在这个由美国国立过敏与传染病研究所（NIAID）资助的STTR项目中，我们将1）确定JX06在体外培养的原代小鼠和人类细胞以及小鼠体内的毒性，并研究其在小鼠体内的药代动力学； 2) 使用小鼠盲肠结扎穿刺 (CLP) 脓毒症模型研究 JX06 在不同小鼠品系中的有效性。 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/5eaf281b-d6c7-45eb-aa4b-87b3699c6a0f/UT1AA030690.png 项目介绍 - 开发天然化合物大黄素用来治疗酒精性心肌病 （NIH UT1AA030690） 酗酒是一个普遍存在的问题，会损害身体的许多脏器，包括心脏。 长期饮酒后可能会出现一种称为酒精性心肌病 (ACM) 的疾病，导致心力衰竭。 ACM 的特点是心肌衰弱和心室扩大。 目前，还没有药物被正式批准用以 治疗ACM。 AcePre 的研究人员正在开发天然化合物大黄素用于 ACM 的预防与治疗。 大黄素具有多种有益作用，包括减少炎症和预防纤维化（过度组织疤痕）。 我们发现大黄素可以抑制转化生长因子β（TGFβ）信号通路，该通路参与心肌纤维化的发生。 我们还观察到，大黄素可以保护心肌细胞免受酒精引起的损伤，并减少小鼠模型中心肌的纤维化。 在国立酒精滥用和中毒研究所 (NIAAA) 的资助下，我们正进一步研究大黄素在 ACM 小鼠、大鼠和猪模型中的安全性和有效性。 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/5db7404f-a694-46f7-bee9-40686ced82e9/R41AG081124.png 项目介绍 - 用于阿尔茨海默病治疗的多功能纳米酶的开发 (NIH R41AG081124) 阿尔茨海默病（AD）是一种进行性神经退行性疾病，是导致痴呆症的最常见原因，痴呆症是记忆丧失和认知能力下降的总称。 它以 Alois Alzheimer 博士的名字命名，他于 1906 年首次描述了这种疾病。该疾病的特征是在大脑神经元中形成淀粉样蛋白斑（一种称为 β-淀粉样蛋白的异常蛋白团）和神经原纤维缠结（tau 蛋白的聚集体），以及神经元之间连接的丧失。 AD 的病因很大程度上尚不清楚，人们认为大脑中的炎症和氧化应激是其发病机制之一。 目前这种疾病无法治愈。 现有药物，包括最常用的药物 Aricept 和最近批准的药物 Leqembi 只能稍微减轻症状或减缓疾病的进展。 迫切需要更有效的药物。 我们 AcePre 的研究人员正在开发一种新的 AD 治疗方法。 我们使用一种具有脑靶向特性的新型纳米粒子（称为 T-CeNP）来输送具有抗炎和抗氧化功能的氧化铈。 我们期望T-CeNP能够有效地进入大脑，在大脑中发挥其强大的抗炎和抗氧化活性，从而减少β-淀粉样蛋白沉积和tau蛋白聚集。 在国立老化研究所 (NIA) 的这项小企业项目资助下，我们将使用 AD 小鼠模型测试 T-CeNP 的安全性和有效性。 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1626890009581-9NLDJ9JS8F2H640X5J74/IMG_9D53ED2EE0F0-1.jpeg 项目介绍 - 使用新型天然化合物 Sparstolonin B 治疗细菌性败血症(NIH R41AI157378) 败血症是由微生物感染引起的，其中细菌是最常见的罪魁祸首。病原体相关分子模式 (PAMP)，例如脂多糖 (LPS)，可激活先天免疫细胞和组织驻留细胞。 其中一些激活的免疫细胞，例如巨噬细胞，会吞噬并杀死入侵的微生物。虽然这些活化的巨噬细胞可以发挥作用，例如杀死微生物和限制感染，但它们也可以通过分泌过量的细胞因子和氧化分子来引起非常强烈的炎症反应，从而导致组织损伤。 这些受损组织释放内源性损伤相关分子模式 (DAMP)，作用于 Toll 样受体 (TLR)，进一步加剧免疫细胞和组织驻留细胞的炎症反应。这会导致多器官损伤并最终导致死亡。细菌性败血症病理学的快速演变和复杂性使其极其难以治疗。我们早先分离出了一种名为 Sparstolonin B (SsnB) 的新化合物，并将其定性为 TLR2/4 拮抗剂。 它可有效地抑制炎症反应。在这些发现的基础上，我们的长期目标是将 SsnB 开发为细菌性败血症的新型治疗药物。 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1626894946401-H6QFZJ1BOHTTVF2W3IQP/IMG_D72C52AAB50A-1.jpeg 项目介绍 - 用于卵巢癌治疗的新型多聚体-金属纳米复合物 (R41CA254500) 卵巢癌是妇科恶性肿瘤死亡的首要原因。大多数卵巢癌 患者被诊断时已是转移性卵巢癌，这种晚期疾病的 5 年生存率低于 28%。 卵巢癌的主要治疗方法是手术与辅助化疗相结合。不幸的是，这些化疗的严重副作用损害了患者的生存质量，导致患者依从性差，并且由于固有和获得性耐药性，复发率很高。因此，迫切需要开发新的安全有效的治疗策略。 我们开发了一种新型pH和氧化还原电位双响应聚合物，聚[(2-(吡啶-2-基二硫基)-co-[聚(乙二醇)]](PDA-PEG)，它可以在细胞内降解。这种聚合物系统作为药物载体，显着提高了癌细胞杀伤效果，并有可能降低所承载化疗药物的脱靶毒性。更令人兴奋的是，后续研究发现，PDA-PEG与铜离子的结合，被称为聚合物金属纳米复合物（PMC）在不负载任何化疗药物的情况下，也可以有效杀死多种癌细胞，包括耐药卵巢癌细胞。重要的是，PMC表现出优异的癌细胞选择性杀伤能力。基于这些先进的技术和令人兴奋的体外和体内结果，我们的目标是最终将 PDA-PEG/Cu PMC 开发成一种安全有效的新型卵巢癌或其他恶性肿瘤治疗药物。 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1626880880276-6FCFY8CXOB1ET7QKJ72Y/IMG_7406B0A2F7F6-1.jpeg 项目介绍 - 开发槲皮素用于治疗肌肉萎缩性疾病 (NIH R43AT011171) 恶液质是指非有意的体重减轻，导致身体机能下降、治疗耐受性降低和死亡率增加。 它常见于慢性疾病和相关治疗。 肿瘤化疗后常出现恶液质。 此外，与恶液质相关的瘦肌肉损失会降低病人对化疗的耐受性。 目前，尚无有效的恶液质疗法。 槲皮素是一种天然多酚，存在于各种水果和蔬菜中，因其抗炎特性和增加线粒体生成的能力而受到认可。 我们已经报道，槲皮素可以减少癌症引起的恶液质，减少与化疗相关的身体疲劳，通过增加线粒体的生成来提高身体机能，并减少许多疾病模型中的炎症。我们的长期目标是将槲皮素与化疗方案结合起来，以减少化疗的副作用，从而提高治疗效果和患者的生活质量。 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1626805391656-Z887EC1RDYF969DXILE5/IMG_0034.jpg 项目介绍 - 大黄素作为辅助治疗以降低5氟尿嘧啶的毒性(NIH R41AT009964) 5氟尿嘧啶（5FU）多年来一直是结直肠癌（CRC）的首选化疗药物。 然而，其非选择性导致的造血和胃肠道毒性仍然阻碍了其临床应用，导致疲劳、食欲不振和腹泻等副作用。 鉴于炎症与 5FU 相关毒性有关，减轻炎症可能会最大程度地减少抗癌药物相关毒性、优化癌症治疗剂量并改善临床结果。 因此，寻找降低 5FU 毒性的策略对于防止治疗中断或剂量下调至关重要。 大黄素是一种存在于多种中草药中的天然蒽醌衍生物，具抑制 NF-κB 激活并减轻炎症的作用。我们发现大黄素是一种有效的抗炎剂，直接作用于NF-κB，能有效减少肿瘤发生，能消除5FU化疗引起的肠道炎症和粘膜炎，并能减轻与化疗相关的其他副作用。我们还观察到，大黄素在其有效剂量下不会产生明显副作用。该项目的长期目标是将大黄素开发成一种化疗辅助性治疗药物。 https://www.aceprehealth.com/cn/new-concept-health-spectrum daily 0.75 2023-11-13 https://www.aceprehealth.com/cn/all-round-health-path daily 0.75 2023-11-13 https://www.aceprehealth.com/cn/relieve-inflammation-and-improve-health daily 0.75 2023-11-13 https://www.aceprehealth.com/cn/top-10-benefits-of-walking daily 0.75 2023-11-13 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https://www.aceprehealth.com/cn/movement-and-silence-in-manuel-antonio-national-park daily 0.75 2026-03-02 https://www.aceprehealth.com/cn/the-pura-vida-rider daily 0.75 2026-03-02 https://www.aceprehealth.com/cn/costa-rica-nature-first-eco-friendly daily 0.75 2026-03-02 https://www.aceprehealth.com/cn/challenge-the-immortal-cancer-msa daily 0.75 2026-03-08 https://www.aceprehealth.com/cn/fatal-negligence daily 0.75 2026-03-08 https://www.aceprehealth.com/cn/unlock-the-secret-of-strawberries-and-the-red-nutrition-bible daily 0.75 2026-03-08 https://www.aceprehealth.com/en/home daily 1.0 2024-07-24 https://www.aceprehealth.com/en/staff daily 0.75 2026-01-25 https://www.aceprehealth.com/en/staff/iris-lo monthly 0.5 2021-07-28 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1627491175703-9Y608B307KP9VG2NRXYS/Screen+Shot+2021-07-28+at+12.45.48+PM.png Staff - Iris Lo - Iris Lo Iris Lo is the Business Manager of AcePre. She holds an Associate Degree in Accounting, and has 22 years of experience in accounting and 12 years of experience in banking. Prior to joining AcePre, she was a Senior Staff Accountant and Controller in The National Educational Telecommunications Association (NETA) from 2001 to 2019 and the Chief Accountant in Allen University from 1997 to 2001. https://www.aceprehealth.com/en/staff/dr-peinsheng-xu monthly 0.5 2021-07-28 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1626721099848-178JL4VQGBO9CC6TWMNQ/Screen+Shot+2021-07-19+at+2.58.07+PM.png Staff - Peisheng Xu - Peisheng Xu Peisheng Xu, PhD, joined AcePre as the Chief Technology Officer (CTO) in 2017. He is a Professor in the Department of Drug Discovery & Biomedical Sciences at the University of South Carolina College of Pharmacy. The primary interests of his lab are design and synthesis of biomaterials and exploring their biomedical applications. The long-term goals of his research are to develop cancer targeted nano-sized drug carrier to eradicate cancer and to design novel drug formulation to alleviate central nervous system diseases. He has been granted 17 granted US and international patents and published about 50 manuscripts in high impact journals. https://www.aceprehealth.com/en/staff/brandon-vanderveen monthly 0.5 2021-08-03 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1628004621488-HK3Q0ROABOSXLFDHP416/VanderVeen+BN+Headshot_8-3-2021.JPG Staff - Brandon VanderVeen - Brandon VanderVeen Dr. Vanderveen is a skeletal muscle biologist and exercise physiologist with a focus on the physiological and biochemical alterations of skeletal muscle that occur in response to exercise, disuse, and chronic diseases. He joined AcePre as a project manager in 2020. He’s directing projects to develop therapies aimed at improving cancer patient quality of life and survival through improving patient functionality. He provides expertise in functional research assessments combined with an understanding of the underlying mechanisms of cancer and chemotherapy-associated muscle wasting related to inflammation as well as mitochondrial quality and function. https://www.aceprehealth.com/en/staff/zhengguan-yang monthly 0.5 2023-07-27 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1627327210954-I9LU7CWNMH9TNU60T6NH/image0.jpeg Staff - Zhengguan Yang - Zhengguan Yang Zhengguan Yang, PhD, PharmD, joined AcePre in 2020 as a project manager. He is a registered pharmacist in South Carolina and uses his knowledge for research and drug development. His roles include developing orally controlled release and sustained release medication dose formulations for in vitro and in vivo evaluation, enhancing oral drug bioavailability, performing Phase I clinical evaluations in human volunteers, performing PK/PD evaluations mouse models and patients. His research expertise is particularly on the roles of DNA damage and repair in human cancer chemotherapy, especially nucleotide excision repair, homologous recombination repair, and base excision repair. https://www.aceprehealth.com/en/staff/kyle-lacio monthly 0.5 2023-11-13 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/5f1a3e74-afcb-45bb-8ac5-c02d25ead815/Kyle+Lacio+headshot.jpg Staff - Kyle Lacio - Kyle Lacio Kyle Lacio joined AcePre in 2023 as the Business Development Officer. He holds a bachelor’s degree in biomedical engineering. He is a Navy veteran with over 20 years of business experience. He works to move AcePre medical research from the laboratory to the market to help patients. https://www.aceprehealth.com/en/staff/yongmei-zhou monthly 0.5 2023-11-13 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/3e2a2777-0f61-47b8-98ab-8240a7c75566/image0.jpeg Staff - Yongmei Zhou - Yongmei (May) Zhou May joined AcePre in 2023 as a Business and Research Assistant. She holds a bachelor’s degree in mechanical engineering and a master’s degree in computer science. https://www.aceprehealth.com/en/staff/angela-murphy monthly 0.5 2023-08-21 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1626720826907-MO1HOAJYEELE75YS5NX1/2020-0226_181+Angela+Murphy+%282%29.jpg Staff - E. Angela Murphy - E. Angela Murphy Angela Murphy, PhD, joined AcePre in 2017 as the Chief Scientific Officer (CSO). She is a Professor at the University of South Carolina School of Medicine. Her research interests are focused on exercise, diet, and complementary and alternative medicine in cancer therapy. She has published over 110 peer-reviewed papers (H-index = 46). As a member of AcePre’s team, her mission is to improve the efficacy of cancer treatments and patients’ quality of life through complementary and alternative medicines. In conjunction with Dr. Fan, she has led an STTR grant funded project on using dietary emodin to reduce the toxicity of chemotherapy. She is also involved in an active SBIR project focused on reducing cachexia associated with cancer and its therapies. https://www.aceprehealth.com/en/staff/daping-fan monthly 0.5 2026-01-25 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1627391510293-8SJ03W7I7F7XKURKLKL2/Daping.JPG Staff - Daping Fan - Daping Fan Daping Fan (MD, PhD) is the Founder & CEO of AcePre LLC. He founded AcePre in order to translate the scientific discoveries and technology innovations made in his own and colleagues’ laboratories into clinical applications to serve patients. He was trained in clinical medicine, molecular and cell biology, biochemistry, and immunology. He is also a professor at University of South Carolina School of Medicine. His research interests include inflammation, cardiovascular disease, cancer, Alzheimer’s disease and related dementias, and muscle wasting diseases. AcePre LLC is dedicated to developing novel therapies for these conditions and diseases. Dr. Fan has published over 140 manuscripts in peer-reviewed journals with an H-index of 50. https://www.aceprehealth.com/en/staff/daping-fan-nbw5a monthly 0.5 2024-03-15 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/0438a9dc-77c1-422a-87b3-f8ff7f3139ae/Christian+Unger.jpg Staff - Christian Unger - Christian Unger Christian Unger, PhD, joined AcePre, LLC in 2024 as a Project Director. He uses his background and expertise in physiology, nutrition, and complementary and alternative medicine to direct projects involving natural compounds. He is interested in developing natural compounds into efficacious treatments for various disease such as Alzheimer’s disease and related dementias, metabolic syndrome, and arthritis. He has developed several novel formulations for natural compounds and filed two patent applications. https://www.aceprehealth.com/en/breaking-down-cancer daily 0.75 2023-08-07 https://www.aceprehealth.com/en/breaking-down-cancer/cancer-and-tumor-staging monthly 0.5 2021-07-06 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1625595319261-W65HEP7OVRUNC5S2LFPG/tumor+staging.jpeg Breaking Down Cancer - Can someone explain tumor staging to me? https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1625595556821-IVXFOS6AYSS9KTQPFSFZ/Screen+Shot+2021-07-06+at+2.17.39+PM.png Breaking Down Cancer - Can someone explain tumor staging to me? - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.aceprehealth.com/en/breaking-down-cancer/grading-cancerous-tumors monthly 0.5 2021-06-30 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1625066566757-BR2T1IVKVBKX3ZX61C7Y/tumor+grading.jpeg Breaking Down Cancer - Can someone explain tumor grading to me? - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1623333908118-SF243J9JMQOKBI9A99J8/TG.2.png Breaking Down Cancer - Can someone explain tumor grading to me? - Make it stand out Nottingham Grading System for Breast Cancer https://www.aceprehealth.com/en/breaking-down-cancer/why-cancer-hard-to-treat monthly 0.5 2021-07-01 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1625060472452-F5I52VSG0OKR5P5YVLMN/Therapy+and+Recurrence.jpeg Breaking Down Cancer - Why is cancer so hard to treat? https://www.aceprehealth.com/en/breaking-down-cancer/what-is-cancer monthly 0.5 2021-07-01 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1625063025895-GAGXAO6AK281LER09E6V/what+is+cancer.jpeg Breaking Down Cancer - What is cancer? https://www.aceprehealth.com/en/types-of-cancer-treatments daily 0.75 2023-08-07 https://www.aceprehealth.com/en/types-of-cancer-treatments/immunotherapy monthly 0.5 2021-07-09 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1625857249496-58A4SA9MENRZWDYT9096/Immunotherapy.jpeg Types of Cancer Treatments - Immunotherapy https://www.aceprehealth.com/en/types-of-cancer-treatments/complementary-medicine-for-cancer monthly 0.5 2021-07-09 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1625857205198-12FEVNJNZSLMOS1DGX0Q/CAM.jpeg Types of Cancer Treatments - CAMs https://www.aceprehealth.com/en/types-of-cancer-treatments/radiation-for-cancer monthly 0.5 2021-07-07 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1625685336633-VWU5V7FASXICOM1UMQ8O/IMG_5B2A8CF03912-1.jpeg Types of Cancer Treatments - Radiation https://www.aceprehealth.com/en/types-of-cancer-treatments/what-is-chemotherapy monthly 0.5 2021-07-07 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1625685315752-4PK54JQNRYGLSF8EZDBI/IMG_640A4F5B76A9-1.jpeg Types of Cancer Treatments - Chemotherapy https://www.aceprehealth.com/en/more-on-chemotherapy daily 0.75 2023-09-05 https://www.aceprehealth.com/en/more-on-chemotherapy/bioavailability-and-chemotherapy monthly 0.5 2021-07-14 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1626275240962-BAWNYXHFL9MGXR446USJ/bioavailablility.jpeg More On: Chemotherapy - What is bioavailability and why is it important? https://www.aceprehealth.com/en/more-on-chemotherapy/side-effects-of-chemotherapy monthly 0.5 2021-07-14 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1626276115543-IJG0XOI1QCEL4IORUNYQ/side+effects.jpeg More On: Chemotherapy - What are common side effects of chemotherapy? - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.aceprehealth.com/en/more-on-chemotherapy/types-of-chemotherapy monthly 0.5 2021-07-13 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1627419893620-HWQ6GVIRMVQQK7L631QI/IMG_640A4F5B76A9-1.jpeg More On: Chemotherapy - What are the different types of chemotherapy? https://www.aceprehealth.com/en/more-on-chemotherapy/what-is-chemo-brain monthly 0.5 2021-07-13 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1626205928850-4956W6IYCHWTWFM3V5WW/chemo+brain.jpeg More On: Chemotherapy - What is chemo brain and do I have it? https://www.aceprehealth.com/en/more-on-cams daily 0.75 2021-06-09 https://www.aceprehealth.com/en/more-on-cams/music-therapy monthly 0.5 2021-09-23 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1632408785504-17KOXZO779HO7KSSRJOU/IMG_0124.jpg More On: CAMs - Music Therapy https://www.aceprehealth.com/en/more-on-cams/how-to-meditate monthly 0.5 2021-07-14 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1626287793707-CJ9JZL5XLHNFNUNG1KX7/flower.jpeg More On: CAMs - How do I learn to meditate? Where do I begin? https://www.aceprehealth.com/en/more-on-cams/benefits-of-meditation-for-cancer-patients monthly 0.5 2021-07-14 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1626285802356-EG0PUDPEHLA4W174BYRB/meditation2.jpeg More On: CAMs - What are the benefits of meditation? https://www.aceprehealth.com/en/more-on-cams/exercise-for-cancer-patients monthly 0.5 2021-07-15 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1626371280063-230VF8IV3X60L725JHUZ/exercise.jpeg More On: CAMs - CAMs: Exercise https://www.aceprehealth.com/en/more-on-cams/acupuncture-for-cancer-patients monthly 0.5 2021-07-15 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1626369942519-6CMC560CCGAVTU59WQVA/acupuncture.jpeg More On: CAMs - CAMs: Acupuncture https://www.aceprehealth.com/en/more-on-cams/meditation-for-cancer-patients monthly 0.5 2021-07-14 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1626284174270-F5TDTL0PB9ZTDTNIGIFV/meditation.jpeg More On: CAMs - CAMs: Meditation https://www.aceprehealth.com/en/more-on-cams/what-are-cams monthly 0.5 2021-07-14 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1626284243425-FBTR23KROXBTLMRCLOLE/CAM.jpeg More On: CAMs - What are CAMs? https://www.aceprehealth.com/en/a-closer-look-breast-cancer daily 0.75 2023-09-05 https://www.aceprehealth.com/en/a-closer-look-breast-cancer/preventing-metastatic-recurrence-of-breast-cancer monthly 0.5 2022-01-03 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/c68b339c-aa2f-435d-a287-54815c3e782c/IMG_0196.jpg A Closer Look: Breast Cancer - Preventing Metastatic Recurrence of Breast Cancer https://www.aceprehealth.com/en/a-closer-look-breast-cancer/egfr-status-and-breast-cancer monthly 0.5 2021-10-11 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1633912924779-4JMW61BIKZ7471FTDB0N/IMG_0126.jpg A Closer Look: Breast Cancer - EGFR Status and Breast Cancer https://www.aceprehealth.com/en/a-closer-look-breast-cancer/breast-density-and-cancer monthly 0.5 2021-09-23 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1632405358542-5W3EYJKLJ3855SHHCLX8/IMG_0119.jpg A Closer Look: Breast Cancer - Breast Density and Cancer https://www.aceprehealth.com/en/a-closer-look-breast-cancer/types-of-breast-reconstruction monthly 0.5 2021-09-13 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1631545856282-OJUDL001O1097WVN7KSS/IMG_F3CB5739E85F-1.jpeg A Closer Look: Breast Cancer - Types of Breast Reconstruction https://www.aceprehealth.com/en/a-closer-look-breast-cancer/types-of-flap-procedures monthly 0.5 2021-09-10 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1631306601290-SR76D2QPY1Z6BFEX3GMV/IMG_24122F1222E8-1.jpeg A Closer Look: Breast Cancer - Types of Flap Procedures https://www.aceprehealth.com/en/a-closer-look-breast-cancer/breast-biopsy monthly 0.5 2021-09-10 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1693925003880-DU2GF7W01Y1A53CWTRTT/IMG_1F4FE20B11F6-1.jpeg A Closer Look: Breast Cancer - Breast Biopsy https://www.aceprehealth.com/en/a-closer-look-breast-cancer/noncancerous-breast-conditions monthly 0.5 2021-09-10 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1631283178531-C5KK0FMCG34HH1N17PB4/IMG_4C6A05888123-1.jpeg A Closer Look: Breast Cancer - Noncancerous Breast Conditions https://www.aceprehealth.com/en/a-closer-look-breast-cancer/brca-gene-mutations monthly 0.5 2021-08-31 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1630430980835-R1FUNNBRPRB9WSUG6539/IMG_36B85051DEAC-1.jpeg A Closer Look: Breast Cancer - BRCA Gene Mutations https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1630431088106-ZULBJVA71ESUXJK4UA9V/Screen+Shot+2021-08-31+at+1.30.55+PM.png A Closer Look: Breast Cancer - BRCA Gene Mutations - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.aceprehealth.com/en/a-closer-look-breast-cancer/breast-cancer-ploidy-and-cell-proliferation monthly 0.5 2021-08-19 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1629401749953-ZHQH4SO9QWQ0IU4DIRI6/IMG_0069.jpg A Closer Look: Breast Cancer - Breast Cancer Ploidy and Cell Proliferation https://www.aceprehealth.com/en/a-closer-look-breast-cancer/breast-cancer-incidence monthly 0.5 2021-08-18 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1629296734445-DDVUKB8JAHBH4UXNQCBI/IMG_0068.jpg A Closer Look: Breast Cancer - Breast Cancer Incidence https://www.aceprehealth.com/en/a-closer-look-breast-cancer/breast-cancer-in-men monthly 0.5 2021-08-18 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1629296580744-2U4GRHLDXFH1IJRB63SW/IMG_0066.jpg A Closer Look: Breast Cancer - Breast Cancer in Men https://www.aceprehealth.com/en/a-closer-look-breast-cancer/side-effects-of-hormone-therapy monthly 0.5 2021-08-13 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1628880957986-WOXXY8ZM484Q2KWOOOE2/IMG_0059.jpg A Closer Look: Breast Cancer - Side Effects of Hormone Therapy https://www.aceprehealth.com/en/a-closer-look-breast-cancer/hormone-therapy monthly 0.5 2021-08-13 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1628880894298-DA9QCWLO53JPY2FAHOS2/IMG_0062.jpg A Closer Look: Breast Cancer - Hormone Therapy DemystifyingBreastCancer_HrmoneTherapy.jpg (817×580) (onco.com) https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1623869732363-B2EOK12CZS55QOPMTKVT/Hther1.png A Closer Look: Breast Cancer - Hormone Therapy - Make it stand out Common hormone therapy drugs. https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1623869767138-I8031G04G8562OOPR49U/Hthe2.png A Closer Look: Breast Cancer - Hormone Therapy - Make it stand out Common hormone therapy schedules. https://www.aceprehealth.com/en/a-closer-look-breast-cancer/side-effects-of-her2targeted-therapies monthly 0.5 2021-08-18 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1629295008887-W52J52HEGC5COJVOGMJA/IMG_0064.jpg A Closer Look: Breast Cancer - Side Effects of HER2-Targeted Therapies https://www.aceprehealth.com/en/a-closer-look-breast-cancer/targeted-therapy monthly 0.5 2023-09-05 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1628881415454-8HCHWP8SD95HIALI8IUV/IMG_0063.jpg A Closer Look: Breast Cancer - Targeted Therapy https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1623874928677-F83PYCYR0TK53C65PYHX/dtlkmls.png A Closer Look: Breast Cancer - Targeted Therapy - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.aceprehealth.com/en/a-closer-look-breast-cancer/staging-breast-cancer monthly 0.5 2021-07-15 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1626380302577-ROYVZPVZ82XUC9PH8QSE/tumor+staging.jpeg A Closer Look: Breast Cancer - Staging Breast Cancer - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1623335801659-3WP3ALCYFO6SK3DL2A66/attempt3.png A Closer Look: Breast Cancer - Staging Breast Cancer - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1623335711650-486NVKRWMLZS1B0C9WLN/attempt2.png A Closer Look: Breast Cancer - Staging Breast Cancer - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.aceprehealth.com/en/a-closer-look-breast-cancer/surgery-and-breast-cancer monthly 0.5 2021-08-13 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1628880843811-5WKHMZV0Q5KB35D1KFUE/IMG_0056.jpg A Closer Look: Breast Cancer - Surgical Removal of Breast Cancer Tumors - Make it stand out 1EE364B59ABA4DE5AED7E559B0D0E0CF.ashx (465×465) (mayoclinic.com) https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1623269601805-B8710VP55DWQLTNBNM4Q/Surgery.1.png A Closer Look: Breast Cancer - Surgical Removal of Breast Cancer Tumors - Make it stand out Reasons a woman may not be able to choose a mastectomy over a lumpectomy. https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1623269689703-EZGSOUZ3HVRJK4C70TL5/Surgery.2.png A Closer Look: Breast Cancer - Surgical Removal of Breast Cancer Tumors - Make it stand out Cases where an ALNB may not be needed. https://www.aceprehealth.com/en/a-closer-look-breast-cancer/types-of-invasive-ductal-carcinoma monthly 0.5 2021-08-13 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1628881193512-UTAA83OZFZM16VITB5MY/IMG_0061.jpg A Closer Look: Breast Cancer - Types of Invasive Ductal Carcinoma https://www.aceprehealth.com/en/a-closer-look-breast-cancer/hormone-and-her2-status monthly 0.5 2021-08-13 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1628881362233-4490LL1T17WH7WYZVJOH/IMG_0058.jpg A Closer Look: Breast Cancer - Hormone and HER2 Status: Why is it important? - Make it stand out hormone-receptor-status-and-diagnosis-430106-color-V12-c330f4d3c9d043aa8b081d2021f3623e.png (1500×1000) (verywellhealth.com) https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1623333031451-U6V5MAGSWBRGPLVA857B/HHS.2.png A Closer Look: Breast Cancer - Hormone and HER2 Status: Why is it important? - Make it stand out Hormone Status Terminology https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1623333078633-8KG1D6H6144JIBJFNEZZ/HHS.3.png A Closer Look: Breast Cancer - Hormone and HER2 Status: Why is it important? - Make it stand out What is included in IHC Hormone Status Test Results. https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1623333123826-OA3JVXQQ51BG3EWVGA6Z/HHS.4.png A Closer Look: Breast Cancer - Hormone and HER2 Status: Why is it important? - Make it stand out IHC HER2 Status Test Results and Meaning. https://www.aceprehealth.com/en/a-closer-look-breast-cancer/types-of-breast-cancer monthly 0.5 2021-08-02 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1627937232765-053J81T1QL49VIY3UNWG/types+of+breast+cancer.jpeg A Closer Look: Breast Cancer - Types of Breast Cancer https://www.aceprehealth.com/en/more-on-immunotherapy daily 0.75 2021-06-10 https://www.aceprehealth.com/en/more-on-immunotherapy/cancer-vaccines monthly 0.5 2021-09-23 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1632408386886-1I9QW8JNI1IRYO2CFQ3J/IMG_0122.jpg More On: Immunotherapy - Cancer Vaccines https://www.aceprehealth.com/en/more-on-immunotherapy/what-are-monoclonal-antibodies-and-what-do-they-have-to-do-with-therapy monthly 0.5 2021-08-02 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1627929779135-FULJ2TO36POW4EKQN9M6/IMG_090F3E29B399-1.jpeg More On: Immunotherapy - What are monoclonal antibodies and what do they have to do with therapy? https://www.aceprehealth.com/en/more-on-immunotherapy/what-is-immunomodulator-therapy monthly 0.5 2021-07-29 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1627579655677-CPAVE3YKMVOQQP9VAFE1/IMG_195285226AA9-1.jpeg More On: Immunotherapy - What is immunomodulator therapy? https://www.aceprehealth.com/en/more-on-immunotherapy/what-is-immune-checkpoint-inhibitor-therapy monthly 0.5 2021-07-29 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1627577086578-O4AJ6LJDE5SQQJ3GNZBV/IMG_3B82DA9A3494-1.jpeg More On: Immunotherapy - What is immune checkpoint inhibitor therapy? https://www.aceprehealth.com/en/more-on-immunotherapy/types-of-immunotherapy monthly 0.5 2021-07-28 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1627504961351-IKHOS5TXLLYEFJUJ1F1V/IMG_EBEA90073523-1.jpeg More On: Immunotherapy - What are the different types of immunotherapy? Illustration of a monoclonal antibody. https://www.aceprehealth.com/en/more-on-immunotherapy/whats-the-difference-between-immunotherapy-and-chemotherapy monthly 0.5 2021-07-28 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1627503542756-H85OHQ3KMTRTD3PMKYCB/IMG_3A79571F7E25-1.jpeg More On: Immunotherapy - What's the difference between immunotherapy and chemotherapy? - Make it stand out 5dabab3f88634.image.jpg (1200×630) (townnews.com) https://www.aceprehealth.com/en/more-on-immunotherapy/what-is-immunotherapy monthly 0.5 2021-07-14 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1626276421357-8JTNXN5BXSXMDGZPCNNY/Immunotherapy.jpeg More On: Immunotherapy - What is immunotherapy? https://www.aceprehealth.com/en/cancer-prevention-and-interception daily 0.75 2021-10-15 https://www.aceprehealth.com/en/cancer-prevention-and-interception/sleep-and-cancer monthly 0.5 2022-01-03 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/55f14c8a-d429-4419-8074-cd00c2921ce7/IMG_0216.jpg Cancer Prevention and Interception - Sleep and Cancer: Are They Related? https://www.aceprehealth.com/en/cancer-prevention-and-interception/the-importance-of-diet-and-exercise-in-cancer-prevention monthly 0.5 2021-12-03 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/c170c22c-56cd-46e2-ab61-12ea8fc12d19/Screen+Shot+2021-12-03+at+8.32.49+AM.png Cancer Prevention and Interception - The Importance of Diet and Exercise in Cancer Prevention https://www.aceprehealth.com/en/cancer-prevention-and-interception/is-cancer-prevention-really-safe monthly 0.5 2021-12-03 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/f339a4c8-2b76-4fd1-a1a5-d77ab338a5ce/Screen+Shot+2021-12-03+at+8.27.07+AM.png Cancer Prevention and Interception - Is Cancer Prevention Really Safe? https://www.aceprehealth.com/en/cancer-prevention-and-interception/the-covid19-pandemic-has-caused-cancer-diagnoses-to-decrease-and-why-thats-bad monthly 0.5 2021-11-04 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/7bcde0f5-b6c1-45ff-bffd-c1eb52e6cf82/Screen+Shot+2021-11-03+at+4.48.17+PM.png Cancer Prevention and Interception - The COVID-19 Pandemic Has Caused Cancer Diagnoses to Decrease, and Why That’s Bad https://www.aceprehealth.com/en/cancer-prevention-and-interception/what-is-genetic-testing-why-is-it-important monthly 0.5 2021-12-03 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/2ea0e69c-31c3-45dd-afa9-4e81e978caff/Gene+Mutations.jpeg Cancer Prevention and Interception - What is Genetic Testing? Why is it Important? https://www.aceprehealth.com/en/cancer-prevention-and-interception/what-are-they monthly 0.5 2021-10-15 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1635279220345-0O4F9SXL46E130CNCSR3/Screen+Shot+2021-10-26+at+4.13.02+PM.png Cancer Prevention and Interception - Cancer Prevention and Interception: What are they? https://www.aceprehealth.com/en/publications daily 0.75 2024-09-05 https://www.aceprehealth.com/en/publications/emodin-bidirectionally-modulates-macrophage-polarization monthly 0.5 2023-08-02 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/6b527268-d051-411d-b0c4-99e904e348bc/Emodin+Bidirectionally.png Published Research - Emodin Bidirectionally Modulates Macrophage Polarization... https://www.aceprehealth.com/en/publications/quercetin-improved-muscle-mass-and-mitochondrial-content-in-a-murine-model-of-cancer-and-chemotherapy-induced-cachexia monthly 0.5 2023-08-02 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/3f8b679d-3abe-4c4f-855f-3c07e8f07807/Quercetin.png Published Research - Quercetin Improved Muscle Mass and Mitochondrial Content in a Murine Model of Cancer and Chemotherap https://www.aceprehealth.com/en/publications/emodin-reduces-breast-cancer-lung-metastasis-s28nm monthly 0.5 2023-08-02 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/8de90ded-0f64-4e7e-abc5-30420441ba38/Emodin+reduces+Breast+Cancer.png Published Research - Emodin Reduces Breast Cancer Lung Metastasis... https://www.aceprehealth.com/en/publications/sub-chronic-oral-toxicity-screening-of-quercetin-in-mice monthly 0.5 2023-08-02 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/25892719-ba1b-4e1b-837b-fadc9a8dc9c4/Sub-chronic.png https://www.aceprehealth.com/en/publications/emodin-reduces-tumor-burden-by-diminishing-m2-like-macrophages-in-colorectal-cancer monthly 0.5 2023-08-02 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/3de53632-5705-43ad-bcdc-a0b12162289b/Emodin+reduces+tumor.png Published Research - Emodin reduces tumor burden by diminishing M2-like macrophages in colorectal cancer https://www.aceprehealth.com/en/publications/safety-of-natural-anthraquinone-emodin-an-assessment-in-mice monthly 0.5 2023-08-02 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/f59bf97b-3f30-4db7-96dd-685a2632c3af/Safety.png Published Research - Safety of natural anthraquinone emodin: an assessment in mice https://www.aceprehealth.com/en/publications/effects-of-emodin-a-plant-derived-anthraquinone-on-tgf-1-induced-cardiac-fibroblast-activation-and-function monthly 0.5 2023-08-02 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/2f5acc9f-fb74-4430-bd8d-25a296a5fca5/Effects+of+emodin.png Published Research - Effects of emodin, a plant-derived anthraquinone, on TGF-β1-induced cardiac fibroblast activation an https://www.aceprehealth.com/en/publications/emodin-inhibits-breast-cancer-growth-by-blocking-the-tumor-promoting-feedforward-loop-between-cancer-cells-and-macrophages monthly 0.5 2023-08-02 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/9bd3813d-ac6e-4b4d-ae0e-de993c504bbb/Emodin+Inhibits.png Published Research - Emodin Inhibits Breast Cancer Growth by Blocking the Tumor-Promoting Feedforward Loop between Cancer https://www.aceprehealth.com/en/publications/emodin-attenuates-systemic-and-liver-inflammation-in-hyperlipidemic-mice-administrated-with-lipopolysaccharides monthly 0.5 2023-08-02 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/b5681e25-3fa2-4dd5-8fcf-c8ecb6abab63/Emodin+attenuates.png Published Research - Emodin attenuates systemic and liver inflammation in hyperlipidemic mice administrated with lipopoly https://www.aceprehealth.com/en/publications/emodin-suppresses-pulmonary-metastasis-of-breast-cancer-accompanied-with-decreased-macrophage-recruitment-and-m2-polarization-in-the-lungs monthly 0.5 2024-04-08 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/34589923-279a-4413-b157-0e05f8bbc91f/Emodin+suppresses.png Published Research - Emodin suppresses pulmonary metastasis of breast cancer accompanied with decreased macrophage recrui https://www.aceprehealth.com/en/publications/panaxynol-alleviates-colorectal-cancer-in-a-murine-model-via-suppressing-macrophages-and-inflammation monthly 0.5 2024-04-08 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/fe7372db-be69-46d2-bfd1-4a56dd5a2b3c/Picture1.png Published Research - Panaxynol alleviates colorectal cancer in a murine model via suppressing macrophages and inflammatio https://www.aceprehealth.com/en/publications/emodin-reduces-surgical-wounding-accelerated-tumor-growth-and-metastasis-via-macrophage-suppression-in-a-murine-triple-negative-breast-cancer-model monthly 0.5 2024-04-08 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1712579003262-M7VORLD2XEDYEI5FK859/Picture2.jpg Published Research - Emodin reduces surgical wounding-accelerated tumor growth and metastasis via macrophage suppression https://www.aceprehealth.com/en/publications/panaxynol-improves-crypt-and-mucosal-architecture-suppresses-colitis-enriched-microbes-and-alters-the-immune-response-to-mitigate-colitis monthly 0.5 2024-04-08 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1712580788474-HRMAWEYCUR1ODDKO6HDF/Picture3.png Published Research - Panaxynol improves crypt and mucosal architecture, suppresses colitis-enriched microbes, and alters https://www.aceprehealth.com/en/publications/potential-of-plant-derived-compounds-in-preventing-and-reversing-organ-fibrosis-and-the-underlying-mechanisms monthly 0.5 2024-09-05 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1712582956610-7INN0W8GDCEFDDV501LB/Picture4.png Published Research - Potential of Plant-Derived Compounds in Preventing and Reversing Organ Fibrosis and the Underlying M https://www.aceprehealth.com/en/publications/breast-cancer-cell-derived-microrna-155-suppresses-tumor-progression-via-enhancing-immune-cell-recru monthly 0.5 2024-09-05 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1725537567189-4BS1TLD1WUJIK21AL7DP/Picture1.jpg Published Research - Breast cancer cell-derived microRNA-155 suppresses tumor progression via enhancing immune cell recru https://www.aceprehealth.com/en/publications/overexpression-of-microrna-155-enhances-the-efficacy-of-dendritic-cell-vaccine-against-breast-cancer monthly 0.5 2024-09-05 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1725538347537-LGMYO2KLR55PDVXLQTRB/mir155-DC+vaccine.jpg Published Research - Overexpression of microRNA-155 enhances the efficacy of dendritic cell vaccine against breast cancer https://www.aceprehealth.com/en/colorectal-cancer daily 0.75 2022-01-31 https://www.aceprehealth.com/en/colorectal-cancer/cancer-remission-ned-and-being-cancerfree monthly 0.5 2022-05-20 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1d42f5a6-981b-4819-9f7e-079f81d73c38/IMG_0250.JPG Colorectal Cancer - Cancer Remission, N.E.D., and Being Cancer-Free https://www.aceprehealth.com/en/colorectal-cancer/colorectal-cancer-prevention-for-highrisk-patients monthly 0.5 2022-05-20 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/20ba0abd-8288-4e22-867c-c97e49922541/IMG_0248.JPG Colorectal Cancer - Colorectal Cancer Prevention for High-Risk Patients https://www.aceprehealth.com/en/colorectal-cancer/screening-tests-for-colorectal-cancer monthly 0.5 2022-03-03 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/a0a3eec2-7231-4f15-9b3a-c31179357026/IMG_0238.jpg Colorectal Cancer - Screening Tests for Colorectal Cancer https://www.aceprehealth.com/en/colorectal-cancer/inflammatory-bowel-disease-and-colorectal-cancer monthly 0.5 2022-03-03 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/9b089297-8a73-41d3-9098-7a174d9feb85/IMG_9BACAC656E2C-1.jpeg Colorectal Cancer - Inflammatory Bowel Disease and Colorectal Cancer https://www.aceprehealth.com/en/colorectal-cancer/lifestyle-and-colorectal-cancer-risk monthly 0.5 2022-03-03 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/a0177aed-dc68-4040-ba83-916c00e207ec/IMG_1A01797FCB1B-1.jpeg Colorectal Cancer - Lifestyle and Colorectal Cancer Risk https://www.aceprehealth.com/en/colorectal-cancer/common-treatments-for-rectal-cancer monthly 0.5 2022-02-02 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/7c60d8a6-1116-4316-8be1-9c6f48d366ed/IMG_0229.jpg Colorectal Cancer - Common Treatments for Rectal Cancer https://www.aceprehealth.com/en/colorectal-cancer/common-treatments-for-colon-cancer monthly 0.5 2022-02-02 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/b0514e8f-bc55-4317-be4c-75b4c4f07b47/IMG_0228.jpg Colorectal Cancer - Common Treatments for Colon Cancer https://www.aceprehealth.com/en/colorectal-cancer/staging-colorectal-cancer monthly 0.5 2022-01-31 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1a7cf06c-30b4-4f6f-958c-3ce92b2adf19/IMG_5494F8E7DA56-1.jpeg Colorectal Cancer - Staging Colorectal Cancer https://www.aceprehealth.com/en/colorectal-cancer/what-is-colorectal-cancer monthly 0.5 2022-01-31 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/fb8d5168-2a82-4655-a0ea-1fc7264a18d3/IMG_D50D5EE5D6DB-1.jpeg Colorectal Cancer - What is Colorectal Cancer? https://www.aceprehealth.com/en/news daily 0.75 2024-09-16 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1623956632227-68J1UKHYNEI2P4AIYFZM/unsplash-image-8XFcmzA4WO8.jpg News AcePre LLC is a privately held biotechnology company that specializes in drug discovery and development. It was founded by Dr. Daping Fan in 2017. The company possesses a strong interest in developing uniquely formulated natural compounds as nutraceuticals to promote health or as prescription drugs to treat various diseases. The company is also dedicated to developing innovative biotechnology-based therapeutics for the treatment of cancer, cardiovascular disease, Alzheimer’s disease, and sepsis. In addition, the company is devoted to providing health educational information for the public. https://www.aceprehealth.com/en/news/2023-h346n-kl8cn monthly 0.5 2023-08-01 https://www.aceprehealth.com/en/news/2022-h346n-kl8cn-hzdeg monthly 0.5 2023-08-01 https://www.aceprehealth.com/en/news/2021-h346n-kl8cn-hzdeg-8hjss monthly 0.5 2023-08-01 https://www.aceprehealth.com/en/news/2020-h346n-kl8cn-hzdeg-8hjss-7w85n monthly 0.5 2023-08-01 https://www.aceprehealth.com/en/news/2018-h346n-kl8cn-hzdeg-8hjss-7w85n-zm2l4 monthly 0.5 2023-08-01 https://www.aceprehealth.com/en/news/2024 monthly 0.5 2024-09-16 https://www.aceprehealth.com/cn/news daily 0.75 2024-09-16 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1623956632227-68J1UKHYNEI2P4AIYFZM/unsplash-image-8XFcmzA4WO8.jpg 新闻 AcePre LLC是一家私营生物技术公司，专门从事药物研究与开发。它由樊大平博士于2017年创立。该公司对开发独特配方的天然化合物作为促进健康的营养保健品或作为治疗疾病的药物有着浓厚的兴趣。该公司还致力于开发基于生物技术的创新疗法，用于治疗癌症、心血管疾病、阿尔茨海默病和败血症。此外，公司还竭力为公众提供健康教育信息。 https://www.aceprehealth.com/cn/news/2023 monthly 0.5 2023-08-07 https://www.aceprehealth.com/cn/news/2022 monthly 0.5 2023-08-07 https://www.aceprehealth.com/cn/news/2021 monthly 0.5 2023-08-07 https://www.aceprehealth.com/cn/news/2020 monthly 0.5 2023-08-21 https://www.aceprehealth.com/cn/news/2018 monthly 0.5 2023-08-21 https://www.aceprehealth.com/cn/news/2024 monthly 0.5 2024-09-16 https://www.aceprehealth.com/cn/publications daily 0.75 2024-09-05 https://www.aceprehealth.com/cn/publications/quercetin-muscle-wasting monthly 0.5 2023-08-21 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/3f8b679d-3abe-4c4f-855f-3c07e8f07807/Quercetin.png 研究论文 - 槲皮素改善癌症或化疗诱导的恶病质小鼠的肌肉量和线粒体含量 https://www.aceprehealth.com/cn/publications/quercetin-toxicity monthly 0.5 2023-08-21 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/30219835-1565-4fd2-be79-f4ba5fba18c1/Sub-chronic.png 研究论文 - 小鼠槲皮素亚慢性口服毒性研究 https://www.aceprehealth.com/cn/publications/emodin-crc monthly 0.5 2023-08-21 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1c29a3b8-9548-46ec-9b7b-a908dd6a4b03/Emodin+reduces+tumor.png 研究论文 - 大黄素通过减少结直肠癌中的M2样巨噬细胞来减轻肿瘤负荷 https://www.aceprehealth.com/cn/publications/emodin-cardiac-fibroblast-2021 monthly 0.5 2023-08-21 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1692628802997-8H1FSSTGAFQ7N7FDNI3R/Effects+of+emodin.png 研究论文 - 植物来源的蒽醌大黄素对TGF-β1诱导的心脏成纤维细胞活化和功能的影响 https://www.aceprehealth.com/cn/publications/emodin-breast-cancer-2020 monthly 0.5 2023-08-21 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/8de90ded-0f64-4e7e-abc5-30420441ba38/Emodin+reduces+Breast+Cancer.png 研究论文 - 大黄素通过抑制巨噬细胞诱导的乳腺癌细胞上皮-间充质转化和癌症干细胞形成来减少乳腺癌肺转移 https://www.aceprehealth.com/cn/publications/emodin-breast-cancer-2016 monthly 0.5 2023-08-21 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1692629838204-QCDHSUN27TTICUF31TRT/Emodin+Inhibits.png 研究论文 - 大黄素通过阻断癌细胞和巨噬细胞之间的肿瘤促进前馈环来抑制乳腺癌生长 https://www.aceprehealth.com/cn/publications/emodin-jbc-2016 monthly 0.5 2023-08-21 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1692630134580-LURCK8JL1ZMJC7D3YFVL/Emodin+Bidirectionally.png 研究论文 - 大黄素双向调节巨噬细胞极化，表观遗传调节巨噬细胞记忆 https://www.aceprehealth.com/cn/publications/emodin-liver-2014 monthly 0.5 2023-08-21 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1692630513070-2UJ1WQECOZ0JZR3ZI5HZ/Emodin+attenuates.png 研究论文 - 大黄素减轻脂多糖诱导的高脂血症小鼠的全身和肝脏炎症 https://www.aceprehealth.com/cn/publications/emodin-breast-cancer-2014 monthly 0.5 2024-04-08 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1692631246988-I9KKW1JTV4O10I86CAJI/Emodin+suppresses.png 研究论文 - 大黄素通过减少巨噬细胞募集及M2样极化而抑制乳腺癌的肺转移 https://www.aceprehealth.com/cn/publications/emodin-safety-2021 monthly 0.5 2023-08-21 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1692631017747-1FU58HDE27JIA9NK7CA4/Safety.png 研究论文 - 天然蒽醌大黄素的安全性：一项小鼠实验评估 https://www.aceprehealth.com/cn/publications/panaxynol-alleviates-colorectal-cancer-in-a-murine-model-via-suppressing-macrophages-and-inflammation monthly 0.5 2024-04-08 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1712578776897-0R0E5XR5LFIF372VY7UC/Picture1.png 研究论文 - 人参炔醇通过抑制巨噬细胞和炎症来缓解小鼠模型中的结直肠癌 https://www.aceprehealth.com/cn/publications/emodin-reduces-surgical-wounding-accelerated-tumor-growth-and-metastasis-via-macrophage-suppression-in-a-murine-triple-negative-breast-cancer-model monthly 0.5 2024-04-08 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1712580315810-QLD0OYMPJPWBPIYSLC4G/Picture2.jpg 研究论文 - 大黄素通过抑制巨噬细胞来减少小鼠模型中手术创伤对三阴乳腺癌肿瘤生长和转移的加速作用 https://www.aceprehealth.com/cn/publications/panaxynol-improves-crypt-and-mucosal-architecture-suppresses-colitis-enriched-microbes-and-alters-the-immune-response-to-mitigate-colitis monthly 0.5 2024-04-08 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1712582711841-GMS7VW7T1OYEDOUC15YQ/Picture3.png 研究论文 - 人参炔醇通过改善大肠隐窝和粘膜结构，抑制肠炎微生物，并改变免疫反应以减轻结肠炎 https://www.aceprehealth.com/cn/publications/potential-of-plant-derived-compounds-in-preventing-and-reversing-organ-fibrosis-and-the-underlying-mechanisms monthly 0.5 2024-09-05 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1712582956610-7INN0W8GDCEFDDV501LB/Picture4.png 研究论文 - 植物源性化合物预防和逆转器官纤维化的潜力及其机制 https://www.aceprehealth.com/cn/publications/breast-cancer-cell-derived-microrna-155-suppresses-tumor-progression-via-enhancing-immune-cell-recruitment-and-antitumor-function monthly 0.5 2024-09-05 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1725537831767-EKXQ4GZK8I8BYPF09F8W/Picture1.jpg 研究论文 - 乳腺癌细胞来源的 microRNA-155 通过增强免疫细胞募集和抗肿瘤功能抑制肿瘤进展 https://www.aceprehealth.com/cn/publications/overexpression-of-microrna-155-enhances-the-efficacy-of-dendritic-cell-vaccine-against-breast-cancer monthly 0.5 2024-09-05 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1725543590185-YQ699IPUD9PY8SFO0JO8/mir155-DC+vaccine.jpg 研究论文 - microRNA-155 过表达增强树突状细胞疫苗对乳腺癌的疗效 https://www.aceprehealth.com/cn/breaking-down-cancer daily 0.75 2023-08-21 https://www.aceprehealth.com/cn/breaking-down-cancer/what-is-cancer monthly 0.5 2023-08-21 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1625161987788-TFLVSZW3SWXY3R0TIOTZ/what+is+cancer.jpeg https://www.aceprehealth.com/cn/breaking-down-cancer/why-is-caner-so-hard-to-treat monthly 0.5 2023-08-21 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1692650876631-XI2KJNFLKBQZFTB6WHJ2/Therapy+and+Recurrence.jpeg https://www.aceprehealth.com/cn/breaking-down-cancer/tumor-grading monthly 0.5 2023-08-21 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1625086647005-3VZGJFA3O6IJVBEBRH9F/tumor+grading.jpeg https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/c2fd1861-072e-4cf4-bcdf-c3a93b577ac1/IMG_2115.jpeg https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1dc0a504-e37e-4d10-8e20-93de03b8064f/IMG_2118.jpeg https://www.aceprehealth.com/cn/breaking-down-cancer/tumor-staging monthly 0.5 2023-08-21 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1692652341693-3HG8Q8F2VD18IUL5P9N8/tumor+staging.jpeg https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/e00ce4a6-15bc-4bf1-92d5-c748fe6ae5b2/IMG_2119.jpeg https://www.aceprehealth.com/cn/types-of-cancer-treatments daily 0.75 2023-08-21 https://www.aceprehealth.com/cn/types-of-cancer-treatments/chemotherapy monthly 0.5 2023-08-21 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1692653421190-CPC8NCD87Y29J79N0HJI/IMG_640A4F5B76A9-1.jpeg https://www.aceprehealth.com/cn/types-of-cancer-treatments/radiation monthly 0.5 2023-08-21 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1692653884972-EYDSV3OC043MCMR4T306/IMG_5B2A8CF03912-1.jpeg https://www.aceprehealth.com/cn/types-of-cancer-treatments/immunotherapy monthly 0.5 2023-08-21 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1692654210257-VDM8Z0APJYNTBV213VZW/Immunotherapy.jpeg https://www.aceprehealth.com/cn/types-of-cancer-treatments/cams monthly 0.5 2023-08-21 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1692654443201-AKEOOEMMRIN5DZ51PWJL/CAM.jpeg https://www.aceprehealth.com/cn/a-closer-look-breast-cancer daily 0.75 2023-09-05 https://www.aceprehealth.com/cn/a-closer-look-breast-cancer/types-of-breast-cancer monthly 0.5 2023-09-05 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1627937232765-053J81T1QL49VIY3UNWG/types+of+breast+cancer.jpeg 深入了解：乳腺癌 - 乳腺癌的类型 https://www.aceprehealth.com/cn/a-closer-look-breast-cancer/staging-breast-cancer monthly 0.5 2023-09-05 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1693915873029-377S2U60S26IY6LWJZSM/tumor+staging.jpeg 深入了解：乳腺癌 - 乳腺癌分期 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/dc270d13-2d0f-4228-9c55-a96a6b0a403c/Staging+Breast+Cancer.jpeg https://www.aceprehealth.com/cn/a-closer-look-breast-cancer/breast-cancer-incidence monthly 0.5 2023-09-05 https://images.squarespace-cdn.com/content/v1/60c0c4ccb585b43df27d5f44/1693916737261-HM2316MF9ZVTAJP9VC7L/IMG_0068.jpg https://www.aceprehealth.com/cn/a-closer-look-breast-cancer/surgical-removal-of-breast-cancer-tumors monthly 0.5 2023-09-05 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